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Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/609eb419af289c18812b4792/1621735617953-ZFINJC6856N2RN2QR6KX/lfischer.jpg Lab Members - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/609eb419af289c18812b4792/1621576158447-EO876J8ZPI8H4OUYWQB8/tmallik.jpg Lab Members - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/609eb419af289c18812b4792/1621579548969-NK7IRB0SKFSAVT86ZO66/jabraham.jpg Lab Members - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/609eb419af289c18812b4792/1621579660311-FAQ89Y667VXXARYZ2FPO/kboltz.jpg Lab Members - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.thefraschlab.org/f1atpase-rotation-mechanism daily 0.75 2021-05-24 https://images.squarespace-cdn.com/content/v1/609eb419af289c18812b4792/1621641513739-023X7IJE86VBVTMSUZ33/negativeea.jpg F₁-ATPase Rotation Mechanism - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/609eb419af289c18812b4792/1621641861874-Q8FL2CMMW1EG1Y6H3JFX/angvelfav.jpg F₁-ATPase Rotation Mechanism - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/609eb419af289c18812b4792/1621641989849-1EFB3X1SLXNSLUTCFPYG/f1xc.jpg F₁-ATPase Rotation Mechanism - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/609eb419af289c18812b4792/1621641374016-C7P74V3K5P61SK37EB4V/elasticcouplingmechanism.jpg F₁-ATPase Rotation Mechanism - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.thefraschlab.org/f1fo-rotation-mechanism daily 0.75 2021-05-24 https://images.squarespace-cdn.com/content/v1/609eb419af289c18812b4792/1621813688109-MFK9J9EBA13SNN7SIOVK/f1fo-lbn.jpg F₁Fₒ Rotation Mechanism - Make it stand out F₁Fₒ in a lipid bilayer nanodisc (LBN) attached to the slide by His-tags (HT), and to the AuNR at the c-ring via streptavidin (SA). https://images.squarespace-cdn.com/content/v1/609eb419af289c18812b4792/1621814059736-7JQ6C7KKFTFFPW319WCF/td-dist-ph5-vs-ph7.jpg F₁Fₒ Rotation Mechanism - Make it stand out Distributions of the % of power strokes containing transient dwells (per 300 power stroke data set) at pH 5.0 vs 7.0, and the misalignment of the Fₒ c₁₀-ring with the 120° positions of the F₁ catalytic dwells. https://images.squarespace-cdn.com/content/v1/609eb419af289c18812b4792/1621813861115-X6ZTBC1U86ARAABU5P0E/fof1-td-example.jpg F₁Fₒ Rotation Mechanism - Make it stand out Counterclockwise rotation during an F₁-ATPase power stroke from an F₁Fₒ molecule where transient dwells (TDs) occur ~36° apart. The first and second TDs for clockwise rotation rotated 10° and 25° (in the ATP synthesis direction). https://images.squarespace-cdn.com/content/v1/609eb419af289c18812b4792/1621814198054-B8AC287QQE23RM7DCF48/cryoem-3-fof1-positions.jpg F₁Fₒ Rotation Mechanism - Make it stand out Cryo-EM structures of the three 120° positions of the rotor relative to the stator. https://images.squarespace-cdn.com/content/v1/609eb419af289c18812b4792/1621814280559-EHPJKYL3QZ7BB624UBZJ/fof1-himedlo-tdeff.jpg F₁Fₒ Rotation Mechanism - Make it stand out Assignment of 120° cryo-EM structures with the high, medium, and low transient dwell efficiencies. https://images.squarespace-cdn.com/content/v1/609eb419af289c18812b4792/1621813531947-LM97JTOPBUG5QV4B23JL/foxc.jpg F₁Fₒ Rotation Mechanism - Make it stand out Cross-section of E. coli Fₒ showing the c₁₀-ring, and the interface with subunit-a helices that have the input and output proton channels. https://www.thefraschlab.org/gold-nanorod-singlemolecule-rotation-assay daily 0.75 2021-05-24 https://images.squarespace-cdn.com/content/v1/609eb419af289c18812b4792/1621358577106-DM716D1T8K47I4PP7B5M/rotpolgif.gif Gold Nanorod Single-Molecule Rotation Assay https://images.squarespace-cdn.com/content/v1/609eb419af289c18812b4792/1621358955882-B04GPBPY04EQ534ZRBB7/rotpol-sine-curves.jpg Gold Nanorod Single-Molecule Rotation Assay - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/609eb419af289c18812b4792/1621637068401-BHXFA5CJ7G87HKX8BPFO/asin-sqrt.jpg Gold Nanorod Single-Molecule Rotation Assay - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/609eb419af289c18812b4792/1621359124345-3TVFGHVSVNMWBEJH117L/regsetgif.gif Gold Nanorod Single-Molecule Rotation Assay https://images.squarespace-cdn.com/content/v1/609eb419af289c18812b4792/1621637091345-9NILY9TRQJ3RB8SCTO1S/alignmin-rotpol.jpg Gold Nanorod Single-Molecule Rotation Assay - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/609eb419af289c18812b4792/1621637497935-TT1GCD5VW6F9XFWU3FLP/offsetpol.jpg Gold Nanorod Single-Molecule Rotation Assay - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.thefraschlab.org/translational-research daily 0.75 2021-05-24 https://images.squarespace-cdn.com/content/v1/609eb419af289c18812b4792/1621877897027-65Y3LBJWAACZ81Z8BXQV/dna-detection.jpg Translational Research - Make it stand out This is the set up for a DNA detection nanodevice. https://images.squarespace-cdn.com/content/v1/609eb419af289c18812b4792/1621878117728-S0VP5KYJPWMIE1R5I2N8/two-city-sequences.jpg Translational Research - Make it stand out We are able to use DNA hybridization and ligation, of two city sequences, via a path sequence to make a molecular computation of the order in which cities are traveled. https://images.squarespace-cdn.com/content/v1/609eb419af289c18812b4792/1621878795321-QLFXWUZ45FRUTT03TYZO/omega-qpcr-2.jpg Translational Research - Make it stand out The Ω-probe DNA strands hybridize to the sequence-specific target to form a loop that can be ligated if the sequence is an exact match. The probe contains sequence information to enable qPCR, which can only happen once the probe has been circularized by ligation. https://images.squarespace-cdn.com/content/v1/609eb419af289c18812b4792/1621877826218-25PR01YROJYOUVOWDGO0/aunr-assay-measurements.jpg Translational Research - Make it stand out Gold nanorod (AuNR) assay for single-molecule rotation measurements. https://images.squarespace-cdn.com/content/v1/609eb419af289c18812b4792/1621877975726-9LN1ZEA0BGFOYFET0H11/lxr-technology.jpg Translational Research - Make it stand out Ligation-Exonuclease Reaction Technology can detect single DNA molecules of a specific sequence. https://images.squarespace-cdn.com/content/v1/609eb419af289c18812b4792/1621878050409-D5DW89LVNQTUI3UKOD5K/dna-computing.jpg Translational Research - Make it stand out Example of a Four-City NP Complete Problem where all cities (A, B, C, D) are connected by paths (P) with varying efficiencies. https://images.squarespace-cdn.com/content/v1/609eb419af289c18812b4792/1621878676501-I4MTPPQXLXS4R3OKMOTM/correct-answer-dna-sequences-2.jpg Translational Research - Make it stand out DNA sequences of correct answers where all cities have been visited, starting and ending with the home city. The number of sequences formed in highest abundance is the optimal answer. https://www.thefraschlab.org/research daily 0.75 2021-05-27 https://images.squarespace-cdn.com/content/v1/609eb419af289c18812b4792/1621467798654-24KY3J0ZBPTV0C2HJ8MB/f1-atpase-rotation-mechanism.jpg Research & Publications https://images.squarespace-cdn.com/content/v1/609eb419af289c18812b4792/1621467726839-CDGNAFO21AU0ANQ27CHR/aunr-single-molecule-rotation-assay.jpg Research & Publications https://images.squarespace-cdn.com/content/v1/609eb419af289c18812b4792/1621467917371-NTY5B2V8DYVT9O6HX2XH/darkfieldmicroscope.jpg Research & Publications - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/609eb419af289c18812b4792/1621818937006-ZPSMTZJ1VM3CE6S8RT6F/f1fo-rotation-mechanism-longer.jpg Research & Publications